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Which Inositol Is Best For IVF Success With PCOS?

Both myo-inositol and D-chiro-inositol have been demonstrated to improve fertility in women with PCOS and myo-inositol has been shown to improve egg quality and IVF success, so which inositol is best? If you are confused about which supplement to take a study comparing the two inositols may help clear the confusion.

Both inositols have special benefit in women with PCOS because they act as unique insulin sensitizing agents; both have impressively reduced circulation androgens, improved insulin sensitivity and improved ovulation rates.

In one study (1) the effects of both inositols were compared in eighty four 'euglycemic' PCOS patients - women with normal glucose levels - who were undergoing ICSI to evaluate which was the best inositol for promoting improved egg quality. Forty three of the participants received 2 grams of myo-inositol twice daily and the remaining women received 0.6 grams of D-chiro-inositol twice daily.

The study results showed that both treatment groups had similar numbers of oocytes at retrieval but significantly there were more mature oocytes in the myo-inositol group and less immature oocytes which can have impact on fertilization rates. In addition, the myo-inositol treated women had more higher quality embryos, and higher pregnancy rates leading the researchers to conclude:

"Our data show that, in PCOS patients having a normal insulin response, myo-inositol treatment rather than D-chiro-inositol is able to improve oocyte and embryo quality during ovarian stimulation protocols."

Myo-inositol is less expensive than D-chiro-inositol too. This study lends further credence to the current trend to supplement myo-inositol in the months preceding IVF/ICSI to help improve success rates.

You should always ask your physician before beginning a new nutritional supplement. This article is intended for informational purposes only and is NOT intended to diagnose, offer treatment or replace medical advice for which you should consult a suitably qualified physician.

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Eur Rev Med Pharmacol Sci.2011 Apr;15(4):452-7. Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Unfer V., et al. Unfer V, et al.,

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