Wayne comes from an occupational surname that originally referred to someone who either drove or built wagons.
One famous bearer of the name is Wayne Gretzky (b. 1961), a retired Canadian professional hockey player who is widely regarded as the best player of all time.
Wayne has been among the most popular baby names in the U.S. since 1880, when data was first collected. It was especially popular (i.e., in the top 50) from 1934 until 1958.