logo
g Text Version
Beauty & Self
Books & Music
Career
Computers
Education
Family
Food & Wine
Health & Fitness
Hobbies & Crafts
Home & Garden
Money
News & Politics
Relationships
Religion & Spirituality
Sports
Travel & Culture
TV & Movies

dailyclick
Bored? Games!
Nutrition
Postcards
Take a Quiz
Rate My Photo

new
Action Movies
Bible Basics
Houseplants
Romance Movies
Creativity
Family Travel
Southwest USA


dailyclick
All times in EST

Full Schedule
g
g Breast Cancer Site

BellaOnline's Breast Cancer Editor

g

Breast Cancer and Heart Disease


The majority of women at risk for hereditary breast cancer have a mutated form of the BRCA 1 or BRCA 2 gene Ė the genes which normally suppress the growth of breast and ovarian tumors. New research now indicates that these women, who are at risk for hereditary breast cancer, may also be at greater risk for heart disease.

A cardiac surgeon at St. Michaelís Hospital in Toronto, Dr. Subodh Verma, states that his research team has discovered that the BRCA1 and BRCA2 genes also regulate heart function.

What does that mean to women who know, or suspect, they may be compromised by mutation to the BRCA1 or BRCA2 genes? And what, if anything, can they do to diminish their risk of heart disease?

According to Dr. Verma, in laboratory studies, mice with the mutated BRCA1 gene had a three-to-five times higher rate of death after a heart attack. The mice suffered profound heart failure, probably due to the fact that their heart attacks were twice as severe as those in mice that did not have the mutated gene.

Compounding the problem, when mice with a mutated BRCA1 or BRCA2 gene were treated with doxorubicin (one of the most common chemotherapy drugs for breast cancer patients), a similar two-fold increase in heart failure was observed. The same results were verified by the research team with human tissues.
Doctors know that doxorubicin is associated with heart failure; however, the new research shows that women with the mutated BRCA1 or BRCA2 gene are even more sensitive to the drugís toxicity.

In simple terms, the research findings suggest that the mutated BRCA1or BRCA2 genes prevent DNA repair in muscle cells that is essential to recovery after a heart attack. Therefore, women at risk for breast cancer may be at an unrecognized risk for heart disease. And it is now understood that breast cancer and heart disease have a common biological basis.

Dr. Verma stressed the important implications these findings have across the board.. Knowing that the BRCA1 and 2 genes are essential to DNA repair may lead to future treatments for anyone with heart disease, a leading cause of death worldwide. Women who carry the mutated gene(s) now know they may also be at a higher risk for developing heart disease in addition to the risk of developing cancer.

As always, bring up your concerns with your medical team. If you suspect you may carry the BRCA 1 or 2 gene mutation, or if this has been confirmed through testing, you will want to monitor your situation very carefully.
Add Breast+Cancer+and+Heart+Disease to Twitter Add Breast+Cancer+and+Heart+Disease to Facebook Add Breast+Cancer+and+Heart+Disease to MySpace Add Breast+Cancer+and+Heart+Disease to Del.icio.us Digg Breast+Cancer+and+Heart+Disease Add Breast+Cancer+and+Heart+Disease to Yahoo My Web Add Breast+Cancer+and+Heart+Disease to Google Bookmarks Add Breast+Cancer+and+Heart+Disease to Stumbleupon Add Breast+Cancer+and+Heart+Disease to Reddit



 



Cortisol, Stress and Breast Cancer
Melatonin and Breast Cancer
Breast Cancer Boot Camp
RSS
Related Articles
Editor's Picks Articles
Top Ten Articles
Previous Features
Site Map


For FREE email updates, subscribe to the Breast Cancer Newsletter


Past Issues


print
Printer Friendly
bookmark
Bookmark
tell friend
Tell a Friend
forum
Forum
email
Email Editor


Content copyright © 2014 by Gail Armanini. All rights reserved.
This content was written by Gail Armanini. If you wish to use this content in any manner, you need written permission. Contact Gail Armanini for details.

g


g features
Money Matters and Breast Cancer

Acupuncture and Breast Cancer

Melatonin and Breast Cancer

Archives | Site Map

forum
Forum
email
Contact

Past Issues
memberscenter


vote
Poetry
Daily
Weekly
Monthly
Less than Monthly



BellaOnline on Facebook
g


| About BellaOnline | Privacy Policy | Advertising | Become an Editor |
Website copyright © 2014 Minerva WebWorks LLC. All rights reserved.


BellaOnline Editor